European Journal of Pharmaceutical Sciences publication


New scientific publication for the APTSol Team. This time the leading journal "European Journal of Pharmaceutical Sciences" with the article entitled "Nanonized itraconazole powders for extemporary oral suspensions: Role of formulation components Studied by a mixture design"

We produced powders containing itraconazole nano-crystals through the combination of High Pressure Homogenization and Spray Drying techniques. These powders have been developed with the intent to use it as a production intermediate for the preparation of extemporary oral suspensions. The role of the various components in getting readily redispersible powder was evaluated through a study of mixtures. The systems obtained showed a greater dissolution performance compared to the untreated product with the techniques adopted, all to the advantage of a better gastro-intestinal absorption of the active ingredient.